Covid infections: COVID-19 infection may accelerate brain aging: study

COVID-19 infections can predispose individuals to develop irreversible neurological conditions, study finds. The finding, published in the journal Aging Research Reviews, also shows that COVID-19 can increase the likelihood of strokes and the risk of developing persistent lesions that can lead to bleeding in the brain.

The team, led by Joy Mitra and Muralidhar L. Hegde, of the Houston Methodist Research Institute, US, noted that extensive research has shown that the impacts of COVID-19 go far beyond the actual timing of the outbreak. ‘infection.

COVID-19 is known to invade and infect the brain, among other major organs, the researchers said.

Coronavirus infection can cause long-term, irreversible neurodegenerative diseases, especially in the elderly and other vulnerable populations, they said.

Several brain imaging studies on COVID-19 victims and survivors have confirmed the formation of microhemorrhage lesions in deeper brain regions related to our cognitive and memory functions.

Researchers have critically assessed the possible chronic neuropathological outcomes in aging and comorbid populations if timely therapeutic intervention is not implemented.

Microhemorrhages are emergent neuropathological signatures frequently identified in people with chronic stress, depressive disorders, diabetes, and age-related comorbidities.

Based on their previous findings, the researchers noted that COVID-19-induced microhemorrhagic injury can exacerbate DNA damage in affected brain cells, leading to neuronal senescence and activation of cell death mechanisms, which ultimately impact the microstructure and vasculature of the brain.

These pathological phenomena resemble the hallmarks of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases and are likely to aggravate advanced dementia, as well as cognitive and motor deficits.

The effects of COVID-19 infection on various aspects of the central nervous system are currently being studied, the researchers said.

For example, 20-30% of patients with COVID-19 report a persistent psychological condition known as “brain fog” where individuals suffer from symptoms such as memory loss, difficulty concentrating, forgetfulness daily activities, difficulty choosing the right words, taking longer than usual to complete a regular task, disoriented thought processes and emotional numbness.

More serious long-term effects analyzed in the study include susceptibility to Alzheimer’s disease, Parkinson’s disease and related neurodegenerative diseases, as well as cardiovascular disorders due to internal bleeding and blood-induced injury. blood clotting in the part of the brain that regulates our respiratory system, following the Symptoms of covid19.

Cellular aging is also thought to be accelerated in patients with COVID-19, the researchers said.

A plethora of cellular stresses prevents virus-infected cells from undergoing their normal biological functions and lets them enter “hibernation mode” or even die completely, they said.

The study also suggests various strategies to improve some of these long-term neuropsychiatric and neurodegenerative outcomes, as well as highlights the importance of the “nanozyme” therapeutic regimen in combination with various FDA-approved drugs that may prove effective in combating against this catastrophic disease.

However, given the ever-evolving nature of this field, associations like those described in this review show that the fight against COVID-19 is far from over, the researchers said, adding that getting vaccinated and maintaining a Good hygiene is essential in trying to prevent these long-term and detrimental consequences.